Imagine coming home after a long day at work, excited to have some close friends over for dinner. You’ve got the groceries in hand, ready to make a delicious meal. But as soon as you open the door, the smell hits you—dog urine.

If you’ve experienced this scenario, you know how frustrating it can be. House-training a dog or puppy is no easy task, especially when you have to leave them alone for a few hours. But don’t worry, we’ve got you covered. We’ve compiled a list of the top 11 best enzyme cleaners for dog urine. Enzyme cleaners contain bacteria that release enzymes to break down the molecules found in bio-waste like urine, feces, or vomit. These cleaners are designed to eliminate both the stink and the stain from your home.

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The 11 Best Enzyme Cleaners for Dog Urine Smells & Stains

1. Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray – Best Overall

Bulldog on Carpet with Hepper spray

Cleaning up dog urine stains can be a challenge, but Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray makes it easy. This product not only removes odors and stains but also binds and lifts them away. It can be used on various surfaces such as furniture, floors, and carpets. Keep in mind to spot test before applying it to a large area to avoid any potential discoloration. Made in the USA with eco-kind components, this product is not only effective but also safe for your home.

Pros:

  • Binds to and removes odors and stains
  • Can be used on multiple types of surfaces
  • The large bottle lasts a long time
  • Made with eco-kind components and has a neutral scent
  • 100% satisfaction guarantee

Cons:

  • Might discolor some surfaces

2. Shout Pets Enzymatic Stain & Odor Remover – Budget Buy

Shout Pets Enzymatic Stain & Odor Remover

If you’re looking for a budget-friendly option, Shout Pets Enzymatic Stain & Odor Remover is a great choice. It can be used on furniture, hard floors, and carpets. While it has a fragrance that some people find too strong, others find it pleasant. However, it is recommended to do a spot test on carpets before using the product extensively.

Pros:

  • Budget-friendly
  • Can be used on multiple surfaces
  • All-around pet mess cleaner

Cons:

  • Strong odor
  • Must test on carpet first

3. Nature’s Miracle Advanced Stain & Odor Eliminator

Nature's Miracle Advanced Dog Enzymatic Severe Mess Stain & Odor Eliminator

Nature’s Miracle Advanced Stain & Odor Eliminator is a great premium spray for various surfaces, including clothes. It has a fast-drying formula and a pleasant smell. However, it is recommended to avoid using it on untreated hardwood.

Pros:

  • Fast-drying formula
  • Can be used on clothes
  • Money-back guarantee

Cons:

  • Strong odor
  • Cannot be used on untreated hardwood

4. Bubba’s Super Strength Pet Odor Eliminator Carpet Shampoo

BUBBAS Super Strength Commercial Enzyme Cleaner

Bubba’s Super Strength Pet Odor Eliminator Carpet Shampoo is known for its industrial strength. It is safe to use on various surfaces and has a longer shelf life compared to other cleaners on the market. However, some pet owners find that their dogs still return to the same area even after using this product.

Pros:

  • Long shelf life
  • CRI approved, money-back guarantee
  • Pleasant smell

Cons:

  • Does not always deter pets from areas

5. Angry Orange Enzyme Cleaner & Pet Stain Remover Spray

ANGRY ORANGE Enzyme Cleaner & Pet Stain Remover Spray

Angry Orange Enzyme Cleaner & Pet Stain Remover Spray gets an honorable mention for its signature orange smell. This product emits enzymatic bacteria for up to 80 hours, continuously fighting odors and stains. However, the scent may be too strong for some people.

Pros:

  • Emits enzymatic bacteria for up to 80 hours
  • Pleasant orange scent
  • Effective on odors

Cons:

  • The scent may be too strong for some people

6. Rocco & Roxie Supply Co. Stain and Odor Eliminator

Rocco & Roxie Stain & Odor Eliminator

Rocco & Roxie Supply Co. Stain and Odor Eliminator is another great enzyme cleaner for dog urine. It is safe to use on various surfaces and comes with a money-back guarantee. Some older stains may require multiple applications.

Pros:

  • CRI approved
  • Money-back guarantee
  • Pleasant scent
  • Can be used on multiple surfaces

Cons:

  • Higher in price
  • Old stains may need a few cleanings

7. Life Miracle Enzyme Cleaner & Pet Odor Eliminator Concentrate – Best Concentrate

Life Miracle Enzyme Cleaner & Pet Odor Eliminator Concentrate

Life Miracle Enzyme Cleaner & Pet Odor Eliminator Concentrate is an eco-friendly option. When diluted with water, this concentrate makes about a gallon of cleaner, reducing waste and saving money. However, some users found that they needed to use more concentrate for effective odor elimination.

Pros:

  • Saves waste
  • Made with all-natural enzymes
  • Gentle scent

Cons:

  • Questionable effectiveness

8. Simple Solution Pet Stain & Odor Remover with Pro-Bacteria and Enzyme Formula

Simple Solution Stain Remover

Simple Solution Pet Stain & Odor Remover with Pro-Bacteria and Enzyme Formula is a versatile cleaner suitable for various surfaces, including carpets, bedding, and fabric toys. It is safe to use around pets and children. Some users have reported that the smell is a bit strong, so it is advisable to use it in well-ventilated areas.

Pros:

  • Budget-friendly
  • Can be used on many surfaces

Cons:

  • Strong odor

9. Sunny and Honey Pet Stain & Odor Miracle

Pet Stain & Odor Miracle

Sunny and Honey Pet Stain & Odor Miracle is an all-natural choice for pet owners looking for an eco-friendly solution. It is safe for pets, children, and people with allergies. However, it may be more expensive than standard cleaners.

Pros:

  • Certified cruelty-free
  • Can be used on many surfaces
  • Comes in three different scents

Cons:

  • Higher in price
  • May require multiple purchases for frequent use

10. Naturally It’s Clean Natural Floor Cleaner

Naturally It's Clean Floor Enzyme Floor Cleaner

Naturally It’s Clean Natural Floor Cleaner is a plant-based option suitable for various surfaces. It is safe to use on hardwood floors, tiles, and even cork surfaces. Some users have found that they needed to use more of the concentrate for effective odor elimination.

Pros:

  • Plant-based
  • Can be safely used on various surfaces
  • Does not need to be washed off

Cons:

  • Needs more than recommended for effective cleaning

11. BioTurf BioS+ Artificial Turf Pet Odor Eliminator Concentrate – Best for Artificial Grass

BioTurf BioS+ Artificial Turf Pet Odor Eliminator

BioTurf BioS+ Artificial Turf Pet Odor Eliminator Concentrate is specifically designed for artificial turf and outdoor spaces. It is safe for surrounding plant life and can also be used on stones, concrete, tiles, and walls. Some users found the scent to be chemical-like, so it is advised to consider personal preferences before purchasing.

Pros:

  • Can be used indoors and outdoors
  • Does not damage real plants and trees

Cons:

  • Scent may not be suitable for everyone

Before making a decision, consider the scent and fragrance preferences, the age of the stain or odor, the location of the cleaner’s usage, and always spot test before applying to a large area. It is also important to keep in mind that these cleaners are most effective when used as soon as possible after the accident occurs.

When it comes to the best enzyme cleaner for dog urine, Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray takes the top spot. Its neutral scent, ease of use, and effectiveness on various surfaces make it an excellent choice. However, there are other great options to suit different needs and preferences.

Say goodbye to dog urine stains and odors with these top enzyme cleaners and enjoy a fresh and clean home with your furry friend!

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